The burden of care and clinical challenges of managing and treating psychiatric and behavioral disorders are immense. It is known that 20% to 60% of patients with neuropsychiatric disorders are treatment-resistant to standard-of-care psychotropic medications. Research and clinical studies now demonstrate a clear connection between infections, inflammation, the immune system, and the brain. 
We will review how streptococcus, Lyme, mycoplasma, and other infections can trigger an antibody response against specific brain targets, resulting in familiar psychiatric and behavioral symptoms such as OCD, anxiety, ADHD, and chronic depression and other common symptoms. 

We will describe how diagnosing the underlying root is critical to providing appropriate and effective treatment for chronic and complex disorders such as PANDAS, PANS, Post-treatment Lyme Disease, and other immune-mediated neuropsychiatric disorders.

We will present case studies examining autoantibodies and their correlation with various neuropsychiatric disorders before and after treatment, as well as their utility in diagnosis and treatment decisions. This information will be a resource and helpful reference for learning more about the diagnosis and treatment of these complex yet treatable conditions.