The understanding of the molecular and cellular basis of ageing has grown exponentially over recent years and it is now recognised that ageing is a complex phenomenon which includes many effects at the systemic level that are ultimately driven by critical changes at the cellular level.  Dr Nichola Conlon will highlight nine key cellular changes that underpin the cascade of events that lead to systemic age-related decline and current/future therapies that can be used in clinical practice to target the hallmarks of ageing and address cellular ageing.

Dr Steve Horvath is a prominent researcher in the field of ageing and molecular biology. He is best known for developing the Horvath Clock, a ground breaking tool that estimates biological age based on DNA methylation patterns. By providing a measure of biological age, the Horvath Clock allows for a more accurate understanding of how ageing affects the body and how interventions such as diet, exercise or drug treatments might be used to influence biological ageing.

Dr Denise Furness' presentation will explore a real-world prospective cohort study conducted in 2023–2024, investigating how diet, lifestyle, and targeted supplementation can influence biological ageing through epigenetic (DNA methylation) clocks. 

Dr Peter Koeppel will share the emerging telomere research that has positioned nucleotides, the conditionally essential building blocks of life, at the heart of healthy ageing. The research reveals the crucial role played by nucleotides in slowing the ageing process through their action on telomeres. In particular the important role that nucleotides play in preventing the degradation of telomeres.

The metabolic system acts as a bridge between the brain and the immune system. Leptin, as a cytokine-like protein, is well-known for its multiple hormonal functions in metabolic regulation, but it is increasingly recognised for its even more fundamental role, hence our reference to it as "permitine" (= the permitting hormone). As the master regulator of all cytokines, it plays a crucial role in providing agency and purpose.

Dr Jill Carnahan will provide a comprehensive overview of strategies for improving health and increasing longevity in the face of modern environmental challenges.  She will explain the role of toxins in longevity and how they contribute to chronic diseases, inflammation, immune system dysfunction, and accelerated ageing as well as highlighting epigenetic factors that will influence an individual's vulnerability to toxins, ageing, and disease, as well as how to personalise health protocols through lifestyle, mind-body and biohacking, and anti-ageing tools.