The understanding of the molecular and cellular basis of ageing has grown exponentially over recent years and it is now recognised that ageing is a complex phenomenon which includes many effects at the systemic level that are ultimately driven by critical changes at the cellular level.  Dr Nichola Conlon will highlight twelve key cellular changes that underpin the cascade of events that lead to systemic age-related decline and current/future therapies that can be used in clinical practice to target the hallmarks of ageing and address cellular ageing.

Dr Steve Horvath is a prominent researcher in the field of ageing and molecular biology. He is best known for developing the Horvath Clock, a ground breaking tool that estimates biological age based on DNA methylation patterns. By providing a measure of biological age, the Horvath Clock allows for a more accurate understanding of how ageing affects the body and how interventions such as diet, exercise or drug treatments might be used to influence biological ageing.

Dr Denise Furness' presentation will explore a real-world prospective cohort study conducted in 2023–2024, investigating how diet, lifestyle, and targeted supplementation can influence biological ageing through epigenetic (DNA methylation) clocks. 

Join Swiss scientist and nucleotide pioneer, Peter Köppel PhD, as he shows how this new longevity research bolsters the DNA repair research he commissioned over a decade ago. This alongside human clinical trials enabled him to formulate unique nucleotide formulas containing a balanced range of naturally-derived nucleotides to complement modern diets.  Translating the science into practical clinical application, multidisciplinary scientist, Rob Verkerk PhD, delves into the overlooked role of dietary nucleotides, emphasising the conditions under which their dietary supply becomes not just beneficial, but essential, to health.

The metabolic system acts as a bridge between the brain and the immune system. Leptin, as a cytokine-like protein, is well-known for its multiple hormonal functions in metabolic regulation, but it is increasingly recognised for its even more fundamental role, hence our reference to it as "permitine" (= the permitting hormone). As the master regulator of all cytokines, it plays a crucial role in providing agency and purpose.

Dr Jill Carnahan will provide a comprehensive overview of strategies for improving health and increasing longevity in the face of modern environmental challenges.  She will explain the role of toxins in longevity and how they contribute to chronic diseases, inflammation, immune system dysfunction, and accelerated ageing as well as highlighting epigenetic factors that will influence an individual's vulnerability to toxins, ageing, and disease, as well as how to personalise health protocols through lifestyle, mind-body and biohacking, and anti-ageing tools.

Dan Buettner is an American author, explorer, storyteller, longevity researcher and public speaker. He co-produced the 3 time Emmy Award winning documentary TV mini series Live to 100: Secrets of the Blue Zones based on his book of the same name, which brings scientifically focused health and lifestyle solutions to help you live to one hundred.