The body continually attempts to eliminate chemical toxins through enzymatic processes in the liver. Urinary D-glucaric acid, a byproduct of Phase I detoxification, is an indicator of chemical exposure to over 200 chemicals. Urinary mercapturic acids are excreted end products of Phase II detoxification. Together, assessing these two analytes provides valuable information about exposure to xenobiotics, liver disease, and the liver's ability to eliminate toxins. This proactive approach to assessing Phase 1 and Phase 2 liver clearance can help identify underlying factors contributing to a long list of health challenges associated with liver compromise.

Learning Outcomes:

• Identify Clinical Scenarios for Hepatic Detox Testing: Recognise when to consider hepatic detox testing in the context of patient symptoms, history of chemical exposure, or suspected liver compromise.
• Understand Sample Collection Guidelines: Learn the proper methods for collecting and handling samples to ensure accurate assessment of liver detoxification markers.
• Explore Key Analytes and Their Significance: Examine the role of urinary D-glucaric acid as a marker of Phase I detoxification and mercapturic acids as indicators of Phase II detoxification efficiency.
• Interpret Results for Clinical Application: Analyse hepatic detox testing results to understand chemical exposures and liver function, and apply this knowledge to develop proactive, personalised strategies that address xenobiotic exposure, manage health challenges, and improve overall wellness.